Recent
Publications:
Ischemic preconditioning
blocks BAD translocation, Bcl-xL cleavage, and large channel activity in
mitochondria of postischemic hippocampal
neurons.
Proc
Natl Acad Sci U S A. 2008 Mar 25;105(12):4892-7.
Epub 2008 Mar 17.
Epigenetic targets of HDAC
inhibition in neurodegenerative and psychiatric disorders.
Curr Opin Pharmacol. 2008 Feb;8(1):57-64.
Review.
CREB modulates the
functional output of nucleus accumbens neurons: a
critical role of N-methyl-D-aspartate glutamate
receptor (NMDAR) receptors.
J
Biol Chem. 2008 Feb 1;283(5):2751-60.
Epub 2007 Nov 30. Erratum in: J
Biol Chem. 2008 Apr 25;283(17):11860.
NMDA
receptor trafficking in synaptic plasticity and neuropsychiatric
disorders.
Nat Rev Neurosci. 2007 Jun;8(6):413-26.
Review.
Formisano L, Noh
KM, Miyawaki T, Mashiko T,
Bennett MV, Zukin RS.
Ischemic insults promote
epigenetic reprogramming of mu opioid
receptor expression in hippocampal neurons.
Proc
Natl Acad Sci U S A. 2007 Mar 6;104(10):4170-5.
Epub 2007 Feb 28.
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Ca(2+)-permeable AMPA receptors in synaptic plasticity
and neuronal death. Lin
Y, Jover-Mengual T, Wong J, Bennett MV, Zukin RS. PSD-95 and PKC converge in
regulating NMDA receptor trafficking and gating. Lebesgue D, LeBold DG, Surles NO,
Morales DM, Etgen AM, Zukin RS, Saatman KE. Effects of estradiol on cognition and hippocampal
pathology after lateral fluid percussion brain injury in female rats. J
Neurotrauma. 2006
Dec;23(12):1814-27. Jover-Mengual T, Zukin RS, Etgen AM. Mapk signaling is critical to estradiol
protection of ca1 neurons in global ischemia. Endocrinology. 2006 Nov 30; [Epub ahead of print] Grooms SY, Noh KM, Regis R, Bassell GJ, Bryan MK, Carroll RC, Zukin
RS. |
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Activity bidirectionally regulates AMPA receptor mRNA abundance in
dendrites of hippocampal neurons. |
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RNA trafficking
and local protein synthesis in dendrites: an overview. |
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Zinc-dependent
multi-conductance channel activity in mitochondria isolated from ischemic
brain. |
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Liu B, Liao M, Mielke JG, Ning K, Chen Y, Li
L, El-Hayek YH, Gomez E, Zukin RS, Fehlings MG, Wan Q. |
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Ischemic
insults direct glutamate receptor subunit 2-lacking AMPA receptors to
synaptic sites. |
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Protein kinase
A regulates calcium permeability of NMDA receptors. |
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Gulinello M,
Lebesgue D, Jover-Mengual T, Zukin RS, Etgen AM. |
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Acute and
chronic estradiol treatments reduce memory deficits
induced by transient global ischemia in female rats. |
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Noh KM, Yokota H, Mashiko
T, Castillo PE, Zukin RS, Bennett MV. |
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Blockade of
calcium-permeable AMPA receptors protects hippocampal
neurons against global ischemia-induced death. |
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Estrogen can
act via estrogen receptor alpha and beta to protect hippocampal
neurons against global ischemia-induced cell death. |
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Induction of
Dickkopf-1, a negative modulator of the Wnt
pathway, is required for the development of ischemic neuronal death. |
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Postsynaptic density
protein-95 regulates NMDA channel gating and surface expression. |
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Calderone A,
Jover T, Mashiko T, Noh KM, Tanaka H, Bennett MV, Zukin RS. |
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Late calcium
EDTA rescues hippocampal CA1 neurons from global
ischemia-induced death. |
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Sun L, Chiu D, Kowal
D, Simon R, Smeyne M, Zukin
RS, Olney J, Baudy R, Lin S. |
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Characterization
of two novel N-methyl-D-aspartate antagonists:
EAA-090 (2-[8,9-dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic acid) and EAB-318
(R-alpha-amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic
acid hydrochloride).J Pharmacol Exp Ther.
2004 Aug;310(2):563-70. Epub 2004 Apr 9. PMID:
15075380 [PubMed - indexed for MEDLINE] |
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Tanaka H, Yokota H, Jover
T, Cappuccio I, Calderone
A, Simionescu M, Bennett MV, Zukin
RS. |
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Ischemic
preconditioning: neuronal survival in the face of caspase-3 activation. |
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Electrical coupling
and neuronal synchronization in the Mammalian brain. |
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Calderone A, Jover T, Noh
KM, Tanaka H, Yokota H, Lin Y, Grooms SY, Regis R, Bennett MV, Zukin RS. |
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Ischemic
insults derepress the gene silencer REST in neurons
destined to die. |
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Hypothermia
rescues hippocampal CA1 neurons and attenuates
down-regulation of the AMPA receptor GluR2 subunit after forebrain ischemia.Proc Natl
Acad Sci U S A. 2003 Mar
4;100(5):2906-10. Epub
2003 Feb 26. PMID: 12606709 [PubMed - indexed for
MEDLINE] |
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NMDA-receptor
trafficking and targeting: implications for synaptic transmission and
plasticity. |
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Jover T,
Tanaka H, Calderone A, Oguro K, Bennett MV, Etgen AM, Zukin RS. |
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Estrogen
protects against global ischemia-induced neuronal death and prevents
activation of apoptotic signaling cascades in the hippocampal
CA1. J Neurosci. 2002 Mar 15;22(6):2115-24. PMID: 11896151 [PubMed - indexed for MEDLINE] |
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Tanaka H, Calderone
A, Jover T, Grooms SY, Yokota H, Zukin RS, Bennett MV. |
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Ischemic
preconditioning acts upstream of GluR2 down-regulation to afford neuroprotection in the hippocampal
CA1. |
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Oguro K, Jover T,
Tanaka H, Lin Y, Kojima T, Oguro N, Grooms SY,
Bennett MV, Zukin RS. |
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Global
ischemia-induced increases in the gap junctional
proteins connexin 32 (Cx32) and Cx36 in hippocampus
and enhanced vulnerability of Cx32 knock-out mice.J Neurosci. 2001 Oct
1;21(19):7534-42. PMID: 11567043 [PubMed - indexed
for MEDLINE] |
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